I loaded a couple set of 125 Noslers for my 300 RUM. The fastest being 100gr of RL22 (3852 fps). I did not get the accuracy that I thought I would get, but the round did get some respectable groups with the best coming from 94 gr of IMR 4350 (3818 fps). I shoot the Remington Sendero and was told the rifling, 1 in 10 might have something to do with it.