RE: Ruger #1 in 25-06 rem
I own the sister of the rifle you are considering. About 20 years ago I swapped a .223 on that #1 in 25/06. At first I thought it might be a mistake. I soon found out it was incredibly accurate and able to handle my varmint to deer needs. My only complaint is the poor trigger setup. I really like the balance of a #1. Amazingly, using a single shot has never been a handicap. It drops deer like they were hit with a poleaxe. With todays bullets, the 25/06 is a very capable caliber.
If you experience accuracy issues, there is a gadget that will probably help. I think they call it a Harris Accurizer. Brownells used to sell them.