If the exact range is known and the deer seems calm, then yes I would do it. I practice at this range, and while I don't have a 50 yard pin I know the correct amount of hold over.

Now if I didn't know the exact range I don't know if I would do it or not. I would really have to be in that situation.

I have never had a deer stop running where I could get a second shot off. They either run till they drop or there is so much cover you can't see them anyway.

Paul