The dead on at 25 yards and it will be 2" high at 100 is not accurate. This thinking does not compensate for large diameter objectives or high mounted scopes.

What if the center of the scope is 2" higher than the center of the barrel. At 25 yards you have made up the 2". At fifty, you are 2" high. At 75 another 2" and 100 another 2". Sure the bullet will drop within the 1st 100, but not enough to compensate for the 8" rise.

The only real way to know where it will hit is to shoot it at the range. I normally make sure I am 1.5-2 high at 100 which should put me in the vitals out to 275 with my .280, 7mm-08, .243, .270 etc.