RE: 270wsm or 25-06
Mike - I don't know what you plan on using the rifle for, but if you're looking for a great long-range deer gun that can go heavier if you need it, look no farther than the .270 WSM. While I don't have one, I do have a .270 Wby Mag, and while the WSM isn't quite that powerful, it is pretty darn close. I am here to tell you that a hunter in North America who does not hunt grizzly needs nothing more than a .270 Wby Mag. That thing has literally hammered elk for me, including one 5x5 at 325 yards, quartering toward me, that took the 150gr Partition on the front shoulder (destroyed), took out a portion of the heart, both lungs, and exited the size of a half-dollar between the last two ribs on the other side of the bull. It sprayed lung matter 3-4' behind the bull, but of course you don't need a blood trail when the game dies in its tracks.
It is also a superlative long-range deer cartridge, with my longest shot being just over 375 yards on a feeding 4x4 muley buck who was standing broadside. The 150gr Partition absolutely dissolved both shoulders and left a nice exit wound (although it wasn't needed: the buck dropped in his tracks). Also, I did not hold over on that buck...now that's flat-shooting!
That being said, even though the .270 WSM is about 200+fps behind the Weatherby round, it should serve you nearly as well.
One other thing to ponder: There really is nothing a .25-06 Rem can do that a .270 Win cannot. However, the .270 WSM was designed to outperform the .270 Win, and it does so by a noticeable margin.
Good Dogwork and Good Hunting