If it would me a one all around rifle, I would opt for the 270 SM the ballistics do look interesting. I don,t think it will do much that the 270 Win won,t do but I can see a little gain in useful range. If you already have a bigger rifle then the 25-06 would get my vote. I must admit though to being kind of a quarter bore nut. For just deer and pronghorn I like my wife,s 250-3000 and I shoot a 257 Roberts as well. All my life I have wanted a 257 Weatherby Mag. I have been thinking of getting a left hand 7mm mag and rebarreling it to 257 Weatherby.