Nope, the lube is a little sticky and doesnt hurt the wad at all. With the real bullets, i shot some in my 45 and the felt wads were glued onto the base of the bullet and then i lubed them with crisco. The sticky lube that you use, will not hurt anything at all. Accuracy wise, the difference i get is using the wads, i'll get atleast 2 out of 3 bullets almost into the next shot. Without the wads, they'll open up to about 1" groups. If you take a look at my target, #1 shot with the BS bullet would be about an inch higher than whats pictured on the target. Use the wad as it comes, dont lube it or do anything to it. Just push it down the bore with your finger, start the bullet and ram it home gently. Its also important to slowly push the bullet/wad down. I had to pull a couple bullets some months back due to the wad flipping over.

Another reason im using wads with BS bullet from now on. In cold weather they group great without wads, But when i was shooting in low 80* weather and not using a wad, they opened up a little over 2" groups. Add a wad and i was getting 2 out of 3 bullets into the same hole. Im almost out of BS bullets and will need to buy a lot more now that i know how they shoot. Im shooting .500" BS bullets that were done in a Lyman cast. They really pack a punch.