With pyrodex, you'll usually get some unburnt powder, thats normal for me. It all depends on what bullet you are using. With triple 7, my 45 can take about 4 rounds before i have to clean the barrel to retain the accuracy. If you're using a sabot, They do load harder with a dirty barrel. If sabots are your case, try switching to a .429-.430 44cal. bullet and sabot " green" They load alot easier for me.

What kind of groups were you getting?

Also, use a damp patch followed by a couple dry patches. Running a dry patch will do no good and is a good way to get your ramrod stuck. Been there done that and it aint no fun.