For deer I use a 130 gr Nosler Accubond. I like it for the flatter trajectory in open country. I would use the 150 if I thought I might stumble into a legal elk.

I had to use the 130s on a big bear last year. I put two rounds into him, the first was adequate, but the second dropped him. My .300 win mag 180'swould have liquidated him on the first tap.