295 grain aerotip powerbelt will work fine on a lung shot mulie. Ive found that powerbelts shoot best in my rifle with between 110-120 grains Loose pyrodex RS. They will hold around a 1" group @ 100 yards. Using a scope and all is fine to see what the rifle and load can do but seeing how you'll be hunting colorado, that scope needs to come off and you'll need to start practing those 150-175 yard shots. I can tell you right now that a mulie @ 175 yards is really tiny looking in the sights. Im not sure what kind of sights you have but if they are the Durabright sights or the plastic stuff, they need to come off and be replaced with the Truglo sights. I bought mine from cabelas for $43 and ended up using the ghost ring due to it allowing me to see my entire target and the surrounding around my target. But the 295 PB With 110-120 grains RS will shoot flat out to 150-160 yards give or take. What unit you hunting?