I would say that it is not the responsible thing to do. It can probably kill a yote but probably not an ethically. As a living creature the coyote deserves more than to have a horrible splash wound I mean you could probably hit but it is not suited for coyotes. What I think Il coyote is saying is that sometimes you have to actuallyhave to do some shooting to find the limitations of the round on your own. And don't use live animals.