Penetration has a lot to do with your set up's overall KE level as well as arrow weight and shot placement. That said I have found through my testing as well as on game that the rage 2 blade heads penetrate very well for theiroverall cutting surface. As to using them on bigger game it comes down to you personal setup. If you are pushing 65 ft/lbs of Ke or better, I think they would work well on bigger game, but keep in mind that as cutting surface increases you penetration will decrease. This means you will have to be aware of shot placement to maximize penetration and the chances of getting a pass through.