The first shot being a different POI is not unusual, many loads will do that. It is caused by the difference between a clean bore and a fouled bore. The fouled bore will have a bit more resistance due to the fouling and will change the dynamics of the shot. When the fouling gets to a certain point it will cause the group to spread even further. This is why for best accuracy most find they need to swab between shots to keep the fouling at a consistent level.

Sometimes a shooter gets lucky and finds a load that will shoot multiple shots into a tight group for several shots before it starts to open up. Others just stay aware of the difference and compensate for subsequent shots. Of course, that assumes the first and second shotsconsistently go to the same places when shot clean followed by fouled, i.e. high and left then centered every time. Others will take the time to swab between shots and still others will hunt with a fouled barrel by firing a squib load before loading.

Good luck with it and it's looking good so far.