First of all I would say you made a very good choice in guns... I own three Tikkas and they all shoot awsome. In my 25/06 I use 49gr IMR 4350 with 115gr Nosler ballistic tips and it is some bad news for deer...As for yotes I use 100gr gamekings over 56gr IMR 4831...Note that the yote load is a very hot load and I only use it when it is very cold...You might want to start some were around 50grs and work your way up from there... As for fur I have to agree with one of the other guys in saying it is hard on hide if you catch any bone, but you didn't say wheter or not you were going to skin them??? Shoot safe and shoot lots!!!