If your main use for your rifle is coyotes then stick with the 22-250 or even at least a 22 hornet. The .17 hmr will kill a coyote, it won't be spectacular and you may have to track the sucker. I have seen a coyote shoot by a friend at 150 yrds with a nef single shot he shot it in the neck and it ran about 50ft. and fell dead. Also don't just look at the price of the rifle when you buy it look into ammo options and cost. I like the .243 and the .223 for coyotes.