Seattlesetters, I think the 338-06 is better but then I'm a 338-06 shooter. The 210gr Nosler Partition is just awesome on Black bears. The 338 has a slightly higher sectional density which usually means better penatration. The 350 is little more than a 35 Whelan with a belt. The two are almost twins. Due to the OAL limit of the 350 it never really lives up to what it could be. The bullet must be seated to deep to take advantage of the case capacity. Remington should introduce loads with 200 and 225gr bullets instead of 250's.