ORIGINAL: Rammer
243 if you buy factory fodder. 6mm if you handload.
Yep. I prefer the 6mm personally. Little bit faster, much more reloading friendly case.
Barrel twist will not be a problem if you have to rebarrel... because you can pretty much pick out the twist you want. Go with a faster twist for your heavier 95-100gr deer/antelope bullets, or a slower one for 55gr varmint bullets.