"with that in mind whats it matter what bullet grain you shoot."

Exactly. My favorite .30-06 coyote load is also my favorite deer load: Winchester case, 150 grain Sierra Pro Hunter or Sierra Boat Tail SP bullet,49-51 grains of IMR 3031 IMR powder and a Winchester LR primer.It really does a trick on coyotes. i've zapped them out tonearly 400 yards with this load.