RE: Need all of your experienced opinions- 22-250 or .220 swift?
IMO neither. The problem with all the 22 caliber cartridges is simple. After 350 yards they run out of energy, and wind "Bucking" ability. Your choices are truly not much better than the .223 Remington. To extend your distance past 350 yards you will need to increase your caliber to at least .243 or .257.
I do not wish to argue the charts with anyone. I have been shooting groundhogs for close to 40 years. When you go past 350 yards, in hunting conditions, you need to upgrade your caliber. Tom.