I shoot a .308 for antelope, but have to agree with game4lunch.
If you already have a rifle for large game, it will probably do with proper load and technique. If you are looking for a new gun, good luck narrowing it down....=0).
.25-06....awesome
7mm-08....awesome
.243 (wssm) win....awesome
.308 win....awesome
Still tons more to argue for and against, but boils down to what you like, and how you shoot.
My 2 cents. As this is the best site for opinions that I have found yet.
Victor