First gun I ever owned was a 338 (for moose). From there I bought a 340 Wby, then a 300 WBY and finally broke down and bought a 375 H&H.

I've used them exclusively for moose, where we hunt deer only 12 Gauges are permitted. I've never used anything smaller so I can't comment on that. I might be weird but my favorite is the 375.

340,