For most of the big game I have shot, I have used a Win. model 70 in .264 Win. mag. This includes Moose, Elk, Mule deer, Whitetail, Black bear, Pronghorn and Bighorn sheep.(and coyotes)

I have also shot some big game with a:
Savage 99 lever .300 savage
Rem. 788 bolt in .243
Interarms bolt 7X57
Rem 7600 pump in .35 whelen
Rem 1100 semi 12 ga (hastings slug barrel)
Enfield replica .58 cal muzzleloader
CVA Express .54 cal double muzzleloader
T/C Encore 209X50 muzzleloader
Savage O/U .222/20ga (coyotes with the .222)

And a Ben Pearson 210 compound bow.

Robin