I have used only 3 different rifles while hnting Mule Deer.
.22-250
.222
.243
Yes I have harvested many Mulies with these rifles and, no, I have never lost one, nor have I had to track one very far. My feeling is regaurdless of what you are shooting, shot placement is the most important aspect. You must feel comfortable with whatever you shoot.

Blackhawk

-----Every day is a great day in Eastern Montana-----