As I understand it, the biggest selling point (advantage) of bullets designed like the Nosler Accubond is that they retain a high % of their orginal mass even after penetrating thick, tough skinned and heavy bone animals (e.g. Elk) to continue to do the damage to hungs, heart, etc.. necessary to bring the big game animals down.
Accubond .300 WM would in my opinion certainly, with a well placed shot take down a deer. It's probably more of a caliber and bullet needed to get the job done for whitetail. But you won't have a problem of the bullet failing to penetrate clear through the deer for sure.
Maybe ask what others who do you .300WM for whitetail use, possibly dropping to a 165 gr bullet?
Just remember the shot placement is still the key to a consistent kill of any game animal.