I've used a 30'06 with 150 grn. bullets (corelock) and while they're not a pea shooter by any means, I would not call them overkill. If those loads do indeed shoot with the same umph as an 06 I would think you'll be fine. The 150 30-06 CoreLoc is a proven preformer on deer, I don't see why it wouldn't be just because there's a little excess capacity in the case it's coming from.