Your talking revolver here? There might be a problem with length of projectile, as it has to clear the frame and the cylinder. Besides that the ball would be cheap, why bother. In fact check the size of 00 Buck shot. whether that would work I could not say. You would not have a lot of range with a handgun. I'd rather use the .44 caliber and shoot a .451 roundball. That should knock the snot out of a yote.