As an old codger I have had 375,338,300 and 30-06. I mostly bow hunt now but have the 30-06 and the rest are gone. Have the Vari-x III on it and if you know how to hunt and don't plan for 400 yard shots this gun will kill it all. I haven't owned the 7mm but sounds like it is a good caliber as well. Point is if you just want one rifle to do it all then the 06 will do it. If I can kill 6x6 bull elk with a little stick then most guns should do the trick as well.