Wazzup Im 15 and I havent used either I have used a 25-06 and its great. I have killed 6 deer 2 hogs and 1 goat and its a great gun. But now i use a .300 with a bullistec tip or a 7mmm Rem. Mag with boat tail hollow point.If you can handle .300 use it or 7mm,out of your 2 choices: .270, 243 is probably tooo small for you