ORIGINAL: ranger140892

Obviously if you want rifle like accuracy, &long range w/ ability to kill, revolvers are out of the question.
I prefer XP100's but they're getting rare. The encore is a great and versatile handgun. There are lots and lots of TCEncore & aftermarketbarrels & cartridges to choose from, and those guns are usually very accurate. I'll probably buy one when XP's become impossible to find.
Probably the most versatile cartridge is the 308 Win. Factory ammo is always there if you don't handload.If you do handload, availablebullet selectioncovers a wide spectrum from 90 gr varmint to 240 gr solids.It's an efficient cartridge with the ability to take any hoofed animal on this continent, or the smallest varmint.
Below is an XP I built a few years ago. Altered factory stock, 308 Win,17" Shilen#5 taperbarrel, Gentry 3 position safety, Farrel base, TPS rings (Leupold QRW'spictured), blah, blah. It shoots sub moa and I've taken many white tail, hogs, coyotes, bobcats, etc with it. 400 yard kills on white tailare a snap if you can hold it steady.