Along the vein of the last two posts I'll say thisEDIT there's been some new posts...sorry)

If there's a decent chance you'll go after the bigger game stay with a 30-06. Trajectory isn't bad at (by my standards...I've made a conscious effort to avoid 'magnumitis'. What on earth did all those hunters use before the 60's?) with 150grain bullets, which are great on deer. (realize a 308 will do everything a 30-06 will but drives the bullet 150fps or so slower...so it's by no means 'out of the running'. )

If there's little chance of the bigger game get I'd look into a 7mm-08 or 270. Flatter, less recoil, and popular enough to provide a good selection at good prices.