my wife and I both shoot 243 with Winchester 100 grain PSP ammo and love them.in all my years of deer hunting with a rifle and that has been a loooooong time,I have only had one get away from me(that was my fault; with a bad hit) my wife has only had one also.
within 250 yards you will have no problem taking a deer.we go for the shot just behind the shoulder bottom 1/3 of the chest.with that you will get both lungs(most of the time) and 1/2 the time get the heart.
As I tell my wife,hit him just behind the shoulder , just above the elbow.

good luck with your choise.