RE: 100 or 125 grain broadhead
If you shoot a shaft that has a lot of flex then you want to shoot a lighter broadhead, because heavier will cause it to bend more and be slower!
Now if you shoot a shaft that doesn't have much flex than you can shoot either depending on which one performs better for you!
Personally I choos a a light broadhead because i like maximize the speed i can get out of my bow, and plus thats just what works for me.