If I was going to varmint hunt, and maybe shoot a few deer I would get a .243

If I was going to deer hunt, and maybe shoot a few varmints I would get a 25.

If you want to keep the pelts of a coyote, you better not get varmint loads for the 25, they will leave a huge exit hole. This is not the case with a 55 or 75gr bullet in the .243.

I have a .243 for varmints, and a .270 for deer size game. Works great for me.