Terry,
I'm a HUGE fan of the 25-06 Rem,and even though you can cross over with it.It makes a long day shooting a ground hogs,if your shooting 100-300 rounds a day.

If this would be a deer rifle and the ocasinoal gopher or coy-dog thenI would say the 25-06.
BUT
I'm not a fan of 243 win either.Since you roll your own I would recomend the 6mm Rem.It will beat the .243 win hands down.It makesa great varmiter and deer round.
Remington make the Modl 700 VLS in the sweet little 6,and it will server you fine on them long outings on ground hogs at 400+ yds.
Take a look.
BBJ