ORIGINAL: metaldonnieg
I believe it's all distance and shot placement. I haven't personally killed one with my 10/22 but I honestly believe it possible if you put the bullet where it should be (in this case probably a head shot). You also have to keep in mind that these things aren't sniper rifles, you should wait for a relatively close shot in my opinion.
Straight from the factory they're not sniper rifles , but with the wealth of aftermarket parts like ported bull barrels and such out there they definitely can become one .