You can be out of centershot with any style of rest.

The easiest way, IMO, to fix this problem is to just take a micrometer (or an old fashioned ruler works too I guess, but the more precisely you measure the limbs the better) and find the center point of the limbs.

I usually throw a little masking tape across the limb and mark a vertical line with a pencil.

After you've found the center of your limbs, line your string up with the mark you made, and then adjust the rest until the tip of the arrow is in line as well, if you are using a release. If you are shooting with fingers, line the tip of your arrow a little to the left side of the string (if you're a right handed shooter) and vice versa for left handed shooters.

Paper tuning will fine tune this for you.

Hope this helps.