ORIGINAL: Todd1700
There is nothing in North America and very few creatures on the planet that I would be afraid to shoot with a 30-06 and a well constructed 180 grain bullet. Our forefathers killed everything in North America with black powder rifles and patched soft lead balls. Yes, they might have been large caliber muzzleloaders but they lacked the power of a modern 30-06. And the projectiles they were hunting with in those old smokepoles can't even begin to be compared to the bullets we have at our disposal today. A 180 grain Swift A-frame, Barnes Triple Shock, Trophy Bonded Bear Claw, or even a Nosler Partition will more than adequately penetrate anything on our side of the pond.
That is exactly right, the 30-06, is almost the perfect caliber, for the NA big game hunter.