That would bug the hell out of me!

If the cable rod is not adjustable the only thing I can suggest is to get an aftermarker cable slide. NAP makes one that holds the cables pretty close to the rod. It appears in your photos that the slide is letting the cables hang out there pretty far. It gets worse at full draw because the force against the rod is greater bending the rod and thus the cables get closer to the center.......and in your way!!! Are the cables crossing in the correct position? I don't know how they are supposed to be on the Guardian, call Bowtech. It will either be above or below the rod. This may be your problem too.

I gained a 16th of an inch clearance from the oem slide, here is a pic of the nap slide on my bow.