One thing that really makes a difference in the answer to your question is what you want to do the most. If you are wanting a gun primarily for deer hunting, and just the occasional yote shoot, then a .270 or 25.06 would rule. But if you want your gun to excel at yotes and only the occasional deer, then a .243 or 6mm would be great, or if you want a pure yote run capable of dropping a deer then a .223 would kick hind end on that department. There are other rifles chambered to excell at one or the other, but these are the most common ones that you will be able to pick up ammo for at any sporting goods store or even a backwoods quick stop in a pinch. Personally, the .243 would be my pick if I wanted a gun that is as close to equal in both small game and medium game potency.