I typically make heart/lung shots. I've killed 4 deer with my .30-06, and 4 with my .243. One headshot with each on does (didn't want to spoil any meat), obviously dropped in their tracks.One chest shot with each, dropped in their tracks. The remaining two chest shots with each resulted in the deer going from 5 to 50 yards after they were hit. I think for cumulative distance, the .243 is slightly ahead...