Okay so I will answer , I think it would be hard to beat one of the 25's with the .264 win mag being my pick. The 25-06 ,.260,257 wthby, are all hard to beat for your purpose. If you hand load the .270 can be loaded down to 90hp that work really well on varmits then you can load up some 130 sp and shoot deer all day long. It will require a scope adjustment for each weight. So if I had to pick just one .264 win mag!!!!!