It depends on your definition of the word "penetrate!"
Is it full or empty?
Is it from the 60's or the present?
Is it a .357 FMJ, SWC, or HP?
What grain is it?
How long is the barrel?
What brand of gun is it?

I'd really rather you pose this question about a "coke bottle" rather than a "can," that way I could aim for the neck!