yeah our deer are 90 percent big Mule deer where i hunt. I have taken most of my deer with the 308, 6.5x55, 270 and 7MM-08. In that order. Its darn close between the 6.5 and 308. The 25-06 would come next followed by the 250 Savage. The only deer I ever lost was with the 243. I have probably used ten other calibers as well.