Yep, no-brainer, shoot. This is a huge buck, offering a good shot. I've shot about 20 deer with bow, and I've never been concerned about them jumping or ducking. I know that they do this, and I know that they're faster than an arrow, it's just never been an issue for me. I think sometimes I've shot low, and had the deer duck right into the arrow. This deer, looking right at you would definitely react. Take your best shot and hope for the best.