you answered your own question ipsc. The 25-06 gives a bit better performance with a heavier bullet. I never said that the 243 is a bad choice it's just the 25-06 is a bit better and that's why IMHO it gets the nod over the 243.
Personally for varmits and yotes my choice is a 22-250 and a 7mag or a .30 round for everything else with the exception of the great bears and Africa where my 375 H & H would be the gun of choice for me.