I have only shot 2 in the neck both dropped in their tracks, luck i guess. The first was 130 yards and hit it dead center in the base of the neck where it meets the shoulders. The second was walking away from me at about 65 yards in the back of the neck. Both shots were with a 30-30 using 170 gr. core-lokts. The only spot i have heard of that drops them every time is the top of the shoulder blade where it meets the spine.