This is a post I know a lot about. I do not take shots at the neck of a deer. I shoot a 22-250, 55 grain ballistic tip, running at about 3600 feet per second. I always shoot does in the head. The bullet explodes making it instant death. I have taken probably 20 does by shooting them in the head and in my opinion, it is the only way to go. Probably the best advice I can give you is that you need to take shots that you feel comfortable with. I have several simple rules for myself.
1. Never shoot at a running deer.
2. Never shoot for the head over 100 yards
3. Never shoot at deer in the brush ( and no matter what anyone tells you, all bullets will deflect.
4. Always shoot bucks in the lungs (must be a broadside shot)
5. Never shoot at any deer where I feel the shot is questionable
(We all owe the deer a ethical, and quick death)

I follow these rules before I take any shot. By doing this every kill I make is satisfying and I am not out at night chasing a wounded deer.
MissouriTrapper