If they are within range (close range,100yds. or less) I allways shoot for the sholder. Last year I shot a doe @100yds. I aimed at her sholder and let the White .504 rip! When the smoke cleared,she was right where I shot her. The 460gr. NE bullet went through her left sholder,crushed her spine,and exited the right sholder with a 3 inch exit wound. There's really not much meat in the front sholder area,and the shot stops them in their tracks!