If I am correct NE Indiana can be flat and reasonably populated. (I am just across the border in OH)
I would use a 222 or 223 with a Hornady SX type bullet with a thin jacket to reduce the chances of the bullet bouncing somewhere you don't want it to go.The thin jacket bullets will not hold up at more than 3500fps (or somewhere near this) so using them in a 22/250 will not work unless you back things down abit.
Sometimes when woodchuck hunting I carry a 22/250 and have passed up shots that I would have taken with a 223 and the thin jacket bullets.