They let you shoot wolves up there?

Expected range has alot to do with my choice. I don't have to worry about anything over 200 yards and I have a .223 Sako. (Wore out my .222 Rem)Ammo is cheap and easy to find. The 22 hornet has its fans, too, but it drops velocity faster and gives less range. These rounds have the advantage of a modest report. I like that because 90% of my shooting is in settled areas.

If wind is a factor, and in many places it is & it really starts to kick your fanny at lower velocities down range, then maybe the various 6mms (.244 cal) would help. Also, wolves are bigger than yotes. Not saying that my .223 won't take one, but if that was my focus, I would step up a notch. Just my preference. Bigger critter, bigger hole.

The 22 250 is also enormously popular hereabouts. Both it and the 220 Swift toss small pills very fast. As one of my high school buddies said, "Yeah, wind is a factor, but they get there faster." Heh, heh. We all have our own needs.